Suvey DB 5 Essay Example | Topics and Well Written Essays - 500 words

Suvey DB 5 - Essay Example This can come in the form of training and perpetual retooling to keep the employee updated in the latest method available that will increase productivity. Employee development enhances productivity not only in terms of making employee effective and efficient in doing their jobs. It also develops loyalty among employees in addition to motivating them to do better with their jobs. Thus, the immediate benefit of employee development is having employees who are motivated and competent who are loyal to the company and therefore likely to stay in the company. The benefits of having competent and motivated employees are in multitude. The most obvious benefit is efficiency and efficacy in doing their jobs. Materials turnover will decline, overhead expenses will lessen and new process will be discovered that will further enhance productivity. In short, expenses will be lessened and output will be optimized by a highly trained workforce wrought by employee development programs (Hameed and Waheed, 2011). The benefit of having a loyal workforce which is a result of an effective employee development program cannot be discounted. While their benefits may not be obvious, their effect can be felt in the organization. Without employee development that will foster company loyalty, there will be high turnover and attrition rate that is not only costly but time consuming as well. Employee recruitment is costly and could be avoided if employees are loyal to the company. The money spent for recruiting new employee could instead be used somewhere else. The lost productivity of an employee who left can also be counted as a cost to the company. In addition, a company has also to spend more resources in training a new hire. After training, a new hire cannot be expected to have the same productivity of the old employee as he or she is still has to learn the ropes of the new job. It takes

Abu Dhabi to Dubai Essay Example for Free

Abu Dhabi to Dubai Essay Fundamentals of road safety have been in the public domain since man started using roads for transport. Traffic accidents have a tremendous effect on the lives of individuals as well as the overall cost of road maintenance and repair in the economy. These losses call for a concerted effort to increase road safety campaigns so as to reduce the number of lives lost in road carnage. Buckle up! Is a call for everyone who wishes to avoid the consequences of neglecting road safety measures. Buckle up! That is what we are always told every time we are flagged down by the police. The know-it-all attitude and our self conscious attitude has never allowed us to fully realize that buckling up can sometimes be the only decisive factor between life and death in horrific accidents. The papers were fresh with screaming titles about the horrific accident that occurred on the Abu Dhabi highway near Ghantoot. The crash pile up of more that two fifty vehicles, the screams, the blazing flames, death and injuries were unimaginable. The scene was reminiscent of of a blockbuster horror movie, utterly unreal yet unfolding in not only one of the best highways but also the busiest twenty five kilometer highway connecting Abu Dhabi to Dubai. Thirty seven people were injured, six of them critically and thirty nine sustained medium injuries. The blazing twenty five vehicles and the poor visibility was not an attractive sight either. Were it not for the excellent rescue, that early morning accident could have led to uncountable deaths. The death toll stood at three but one more person died while undergoing treatment. The armed forces , the Dubai police and the many support teams organized an excellent rescue system where the injured were rushed to the nearest hospitals. This horrific pile up was later blamed on the over speeding in the poor weather. It was very early in the morning , I had left my husband in the house at our Al Rhabha apartment to catch a taxi to Dubai International airport. The call was strange, the caller barely hissing through. He didnt know what was happening. Then a more audible voice boomed through and informed to him that I had been airlifted by a life flight helicopter from the accident scene just minutes ago. On my condition, the doctor could only tell my husband a single word â€Å"critical. He rushed to the hospital and for the first time in his life he felt utterly confused and restless, he wasnt even sure if I was going to die or live and to make it worse we had only been married for three months. What a misfortune! He thought. Was this going to be the worst experience in his life? Still unconscious, wreathed in bandages, pale and out in my own land, I could not even barely imagine the pain that engulfed my loved ones as they by lay vigil each night, thinking of my sorry picture with only breathing tubes to hang onto. On the second day, I regained consciousness and began a hazy recollection of what happened. The successive bumps and crash. I could recall seeing the driver ram straight into the car in front, a second later I was flung head first into the driving seat almost unsitting the driver who nonchalantly pushed my head aside. The only other recollection is seeing flames and being suffocated by fumes of burning petrol. The accident left me with gruesome facial cuts, an upper broken jaw with six teeth less. In modern day United Arab Emirates, the causes such accidents are as varied as the number of accidents. There are times when you cant really blame anybody. Nobody expects a sudden thick fog during the rush hour, it was quite an unfortunate scenario but you dare not snarl in the highway because you could be the cause of another accident. The combination of reckless over confident drivers with such weather conditions only spells doom to the careful drivers who will slow down and ensure that there is sufficient space between his vehicle and the next but there is no knowing who might ram into your rear. It is therefore an unwritten rule that one simple mistake like slowing down even in zebra crossings might result in traffic accident. Despite all these unwritten rules, you cannot surely escape being labelled a very stupid person if you drive at 120km/h in a silly thick fog. It is always the first car in the crash that causes the accident, whether he was driving beyond the police legal allowance, a copy of the many paper on the driving wheel or coffee on the other hand, the prerequisites to such traffic accidents are seen every day on our highways. It gets even more harrowing when people drive while answering phone calls or when rich spoilt kids zoom at dangerous speeds in brand new SUVs. I was dispatched from the hospital after three intensive months of medical care. By slowly recollecting the past, trying to shift what might have caused the accident and what might have not, trying to find a rationale why as a passenger I had much more serious injuries than the driver who only escaped with minor injuries the answer to my stupid injuries hits me hard, Buckle up! : That was the difference between the driver and me. Its even more hurting that I had to learn painful way. The seat belt usage is the savior if you are to be involved in such accidents. These are a very many road casualties that arise due to our refusal to buckle up. Presently the campaign â€Å"Your safety is in using safety Belt is helping people understand the importance of buckling up. Additionally, as we speak now heavy fines are being levied on those apprehended for not putting on their safety belts. This has come only after the realization that traffic accidents cause more deaths than murder and is only second to death caused by cardiovascular diseases. The experience of accidents is harrowing, the survival chance is in guaranteed, and as more and more lunatic drivers are released onto our roads, the only savior is the seat belt. I have never been reminded to buckle up ever since, my scars are too huge to be ignored. Buckling up has become an innate predisposition to me. References New Initiative in IAHVs Road Peace Campaign: Buckle up Dubai www. dubaishopping festival. com/news/IAHV11-09. htm Buckle up Drive Controls Violations of Seat Belt Rule. 2007http:www. uaeinteract. com/docs

Inaugural Address to the People of the US :: essays research papers

Inaugeral Address to the People of the US   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Hello ladies and gentleman, citizens of the United States of America. Today I will be reading to you my inaugural address, and will hopefully cover any and all issues or questions you may have about why you should, and trust me, you should, vote for me to be your president. The ten issues I will be addressing in my speech are: education, medical care, employment, welfare, crime, drug trafficking, language, environment, media, and abortion. Let me start with education.   Ã‚  Ã‚  Ã‚  Ã‚  Education is not something to be taken lightly. To many kids today are not getting sufficient education, starting as soon as kindergarten. My plan for education is to set guidelines and standards that will be relevant in every school. By a certain grade, each student should have been taught everything sufficient for that level of education. This way all students will have been taught the same amount of information at the same time. I would take away AP classes and instead put children who learn at an accelerated rate in their choice of a grade above their current level, or at a school specifically designed for children of their intelligence. This way in public schools, children not in AP classes will not in any way feel inferior. I will press for smaller classes, and more teachers, that way, children can get more individual attention that so many of them need. I will also make it so that colleges must pay more attention to the motivation of the student rather then the grade point average. To often high school students get rejected from colleges because their grade point average doesn’t meet the standards of a certain school.

Problems on Fraternity Membership

The Problem and Its Background Introduction Fraternity nowadays is very popular in Universities, Colleges, and Communities. Some of them have their own experience in a Fraternity. In a Certain University here in Philippines there are some Known Fraternity such as Tau Gamma Phi, Alpha Phi Omega, Alpha Kappa Rho etc. ut this Fraternities are much known by the Students than the Administrators of the Schools. There are different types of discrimination. Black people in America experienced it as well as Asians, Cubans, Mexicans and other non-American living there. It is commonly called racial discrimination. People with physical deformities suffer the so-called physical discrimination. People who belong to the third sex are also victims of such cruelty. Now, new sets of victims have risen. They are the students who member of fraternities and sororities.Discrimination of fraternities and sororities arise because other people think that these fraternities and sororities only cause troubles, which the members do not agree with. Those students who join the fraternities or sororities are not merely looking for trouble but there are deeper reasons, like to have a group they can call their own, to experience good camaraderie, brotherhood and sisterhood and to have lots of friends. These are a fact that others do not see, that is why they jump into conclusion that fraternities and sororities cause trouble so they deserve to be discriminated.We all know that discrimination has many effects on the life of an individual. This study the researcher is out for the truth. This researchers carries the purpose of finding out the effects of fraternity and sorority discrimination. Statement of the problem This study will seek answers to the following questions. 1. Why do college students who are involved in fraternity or sorority discriminated in school? 2. What are the main reasons why they joined fraternity or sorority? 3. What are the advantages in joining fraternity or sorority? 4 . What are the disadvantages in joining fraternity or sorority? Objectives of the studyGeneral Objective: The main objective of the study to determine the problems encountered by the membership in fraternities. Specifically, this study aims: 1. To find out why to join Fraternity 2. To be aware about the Problems such Organizations undergo 3. To identify the nature of brotherhood and sisterhood as Fraternities and sororities 4. To have a knowledge about the Basic 5. To know the advantages and disadvantages of Fraternity Significance of the study This study signifies that.. ~ Expose the discrimination experienced by the students who are involved in fraternities and sororities in school. Correct the misconception people have regarding these fraternities or sororities. ~ Inform students about the positive and negative effects of joining the fraternity or sorority. ~ Give an overview why students want to join fraternity or sorority. Assumptions These are the reasons why students joined a fraternity and sorority, and there are fraternities and sorority members who are responsible and can perform well in school. There are fraternities and sororities who can help students develop their self-esteem and self-confidence. And there are fraternity and sorority who can give protection and support to its members.There are preventive measures that can be done when someone wants to join a fraternity or sorority. There are fraternity or sorority who conducts physical initiations rites. And there are possibilities that when a students joined a fraternity or sorority, his social life and attitude will change. Scope and delimitations This study will deal only problem faced by being a fraternity member on the life of a student in selected college/university. This will be done through interviewing 20 members and non-members of different fraternities or sororities in four different colleges/universities namely, St James College Of Q.C, University of Santo Tomas, Our Lady of Fatima Un iversity, and Centro Escolar University. Chapter II Review of Related Literature and Studies This chapter will discuss on the information that have significant bearing on the process and discussion of research.. According to the â€Å"Webster Dictionary Encyclopedia Edition. †, fraternity is an organization for social or other purposes of student in colleges who usually have the Greek letter names and secret rites, and represented by chapters in many Institutions. Fraternities were established with an avowed purpose of offering friendship, leadership, nspiration, guidance and services to the students and other people As well. College fraternities. Are far more ahead from their contemporary high school Fraternities, in some colleges, forming an organization or fraternity is legal, because of the fact that the members, whether students or alumni, the advantages of fraternal organizations are not only astounding but self evident. They believe that it helps maintain the high-qual ity attitude of the campus and strengthen the function of higher education in social mobility. But not all fraternities have the same outcome in other campus.According to the article of Alfred McClung, to non members, their disadvantages are overwhelming, and their presence on the campus is regarded as hurtful and hostile to the objective of higher education, they believe that fraternity members are war freaks, cause nothing but trouble in the school that they are in, in that same article, the point of school authorities, fraternities have served no good, they have been continual source of problems for disciplinary officers and administrations of the campus, Forming a fraternity is therefore prohibited. According to William S. Carlson, the liabilities of fraternities in student’s life are ery different in kind and severity from one campus to another, the most negative criticisms are directed toward those on the large, heterogeneous campuses, where there are the highest contra st in economic origin, social consciousness, social skills and competence. The lack of security in social relations is therefore the greatest concern to the student, parents and school administrators, however, banning fraternities as many schools now ban them has really forced this fraternities to go underground but there are still some fraternities, which are recognized by the school authorities and students but not ecognized by the school administrators, In an article entitled, â€Å"Psychological Needs of Adolescents,† it was stated that college students enter in a fraternity for brotherhood and for protection.Fraternity members voluntary joined hands in recognizing that true brotherhood emanates from love and respect for their fellowmen. According to Joseph Rhulman in his book â€Å"Personnel Principles in Chapter House† the reason behind why college students enter organizations such as fraternity, because of curiosity and peer pressure, in the youth sub-culture of almost all generations he peer group is more powerful influence than admonitions of parents and school authorities. There are ample data to show the ultimate erect of the college discrimination especially in regard to the earning trust of the students. In a typical university, the fraternity feels that it must make its entrance in style, being sure that it can compete with the long established group already present that is why they develop their own principles in recruiting new members.Nowadays, many college students are aware with the mindless and useless death due to hazing. This barbaric practice which defies all norms of civilized conduct has ecome institutionalized establishments of higher learning is beyond understanding. Some fraternity members say that it is intended to instill discipline among unruly freshman and newly recruits, but the countless deaths and injuries it has caused seemed to militate against this cruel practice. That is why, most non members get intimidate b y the way the members act. For instance, the fraternity riots that are breaking out. These non members are in fear that their lives might be in jeopardy. They suggest that the best way to do to have a clean –image-fraternity is to completely abolish hazing.In the article â€Å"Tougher Laws Alone Won’t Stop Hazing and Abuses,† says that there is no justification for mindless violence and risk to life. However, the better remedy is to meet the needs of college students by means of more professionally oriented organizations. To give young men in our colleges and universities enough challenges and interesting tasks as well as stimulating academic activities to keep their minds focused on these priorities rather than their socializations needs alone, Another way is to say that the socialization needs will be met by the overall challenge of school activities and the xpectations given to young people to develop themselves without need for fraternities. Loss of life is certainly a better option to prevent these students from joining these Fraternities.Chapter III Methodology The survey type of a detailed analysis of a group, was used in this study since this study concerns about the present conditions regarding students who are involved in a fraternity or sorority the analysis of this condition will lead to the understanding and possible solutions to the problems undertaken by the researchers Methods Used In order to obtain the data which are important in the course of study, a case study s an appropriate method used. Case study is a detailed analysis of a person or group Profile of the respondentsThere are 20 college students, ages 17-27 years of age, all Males, all singles serve as the Respondents and all of which were members of such Organizations or fraternities, among these respondents, 4 of which agreed to give such information about themselves which will be crucial in this research, Goy (not real name) a 18 year old college student from St James College of Quezon City, single and have been a member of a unsaid fraternity for two years now, â€Å"Nuno† (not real name) a 27 ear old alumni of Fatima College, single and have been a member of Tau Gamma Phi fraternity for nine years and still active and helping the growth of his fraternity, another one is â€Å"olsen† (not real name) a 19 year old student from University of Santo Tomas, single and also a member of Tau Gamma Phi for 3 years now, and last is â€Å"Bok† also a 19 years old student of Centro Escolar University, single and have been a member of his fraternity for 3 years now. Data gathering Procedure Library- based research. The researchers obtain some information from the library and v visit some websites.Primary source of information such as books, articles and other publication are gathered. Secondary source of data were taken so that these materials will also provide information. Observation. The researchers have observed the respondents and studied the demographic profile of the subjects. Studying the location of the subjects will help fully understand the condition of the respondents since they came from various learning institutions. Interview. The researchers conduct queries in order to gather data. A structured questions are prepared . Survey. A questionnaire containing four (4) questions with multiple options re used . These questionnaires were administered to facilitate the validity of the data gathered. Instrumentation The researchers use questionnaire which has four questions with multiple options given to gather data for the study. Those questions are related to the problem statement. Sampling Techniques and Procedure Driven by the researchers need to gather information, the researchers choose lottery method in choosing the respondents for this research, In that case, the researchers will be able to better gather information without being biased in some information which he researchers consider important in this research, and also gather information without compromising the integrity of the data being shown. Q U E S T I O N N A I R E Dear Respondents, We, the students enrolled in Society and Culture of FEU-Fern College are working on the research entitled, â€Å"Problems Facing Fraternity Membership†. This is in partial fulfillment of the requirements in the said subject. Rest assured that whatever information will be gathered will be used for research purposes only and will be treated with utmost confidentiality. Thank you very much. Very truly yours, The Researchers ———————————————————————————————————– Name: ( optional)_______________________ Age:____________ Gender:_________ Course:__________School:__________ Direction. Pleas e read carefully each question. Each question has multiple options, you may have multiple answers. Kindly answer the questions honestly and completely. 1. What fraternity are you currently engaged? ?Alpha Phi Omega ?Tau Gamma Phi ?Beta Sigma ?Upsilon ?Alpha Kappa Rho ?Scout Royal Brotherhood ?FROKS ?Delta Sigma Phi ?Sigma Beta Phi ?Alpha Phi Beta ?Beta Lambda ?None . Is it authorized in your school? Yes ?No What/Who encourage you to join the fraternity? ?Political Machinery ?Security and protection ?Socialization ?To be popular ?To have a feeling of belonging ?Invited by Friends ?Help others ?Curiosity ?Peer Pressure ?For improvement ?Others ?No Organization What do you think are the advantages or disadvantages of joining Fraternity or Sorority? ?To be popular ?Have lots of friends ?Can do well in school ?Can get support during elections ?Practice my right to say yes or no ?Connection when you graduate ?Full of riots ?Death Chapter IV Analysis of Data 1. What fraternity are you curr ently engaged? Tau Gamma Phi ( 25% )Alpha Kappa Rho ( 20% ) Scout Royal Brotherhood ( 15% ) Delta Sigma Phi ( 15%) Alpha Phi Omega ( 10% ) Beta Sigma ( 5% ) None ( 10% ) Total: 100% 2 Is it authorized in your school? Yes ( 0%) No ( 100% ) Total: 100% 3. What/Who encourage you to join the fraternity Socialization (20%) Security and Protection (15%) Invited by friends (13%) Curiosity (12%) No organization (11%) Peer Pressure (9%) Help others (9%) To be Popular (8%) Others (3%) Total 100% 4. What do you think are the advantages or disadvantages of joining Fraternity? Connection when you graduate (20%)Have lots of friends (18%) Can do well in school (15%) To be popular (12. 5%) Full of riots (12. 5%) Death (12. 5%) Practice my right to say yes or no (9. 5%) Total 100% Chapter V Summary of Results and Findings. Most of the fraternity members do not feel the problems physically, emotionally and socially. Most of those fraternities are unauthorized in schools, they join fraternities to hav e a better social life, security and protection and gain more friends, all of them answered that fraternity members do not deserve this problems. Most of the respondents have the same reason that there is nothing wrong with being a raternity or sorority member. Recommendations This research is highly recommended to all students especially in college levels who are already aware of such existing organizations; the proponents’ put stress into this research to show the students what are the problems encountered by the members of fraternities. Conclusion The group concluded that Problems facing fraternity is inevitable. According to the data gathered and answered questionnaires it shows that students join fraternities primarily because of security However some students have their own reason why they do not join such organization.Bibliography â€Å"Fraternity,† Webster Comprehensive Dictionary Editions, vol. I p 502 Alfred McClung, â€Å"Fraternities Without Brotherhood,â €  (Boston Beacon Press, 1995)p. 445 Ibid (as no. 2) William S. Carlson, â€Å"Fraternities: Evil Force on the campus,† Saturday Review (September 10, 1985)pp. 59-61 Psychological needs of the adolescents,† The Philippine journal (dec. 18, 1996) p. 10 Joseph Rhulman, â€Å"personnel Principles in chapter house† (Washington American Hill Brother Company, Inc. 1988)pp 24-26 McClung, loc. Cit Carlson, loc. cit ———————– [pic] [pic] [pic] [pic]

AIDS/HIV

Acquired Immune Deficiency Syndrome (AIDS) is the progression of the Human Immunodeficiency Virus (HIV).   AIDS is the final stage of the development of HIV.   Without receiving treatment, an HIV infected person usually develops AIDS within ten years (Advert.org, 2007).   In order to understand AIDS, you must understand where it comes from: HIV.HIV is a virus, transmitted from one person who is infected to another person who is not infected.   HIV attacks the immune system and kills a specific system cell called a CD4 lymphocyte (Advert.org, 2007).   HIV is a rapid mutating virus, which helps it form being destroyed by the immune system’s natural defenses.According to the Center for Disease Control and Prevention (CDC), the first human case of HIV appeared in a male from the Democratic Republic of Congo in 1959.   It is unknown exactly how he became infected (CDC.gov, 2007).   The CDC stated (2007):â€Å"For many years scientists theorized as to the origins of H IV and how it appeared in the human population, most believing that HIV originated in other primates.Then in 1999, an international team of researchers reported that they had discovered the origins of HIV-1, the predominant strain of HIV in the developed world.   A subspecies of chimpanzees native to west equatorial Africa had been identified as the original source of the virus.The researchers believe that HIV-1 was introduced into the human population when hunters became exposed to infected blood† (CDC.gov, 2007).In America, the first cases of AIDS occurred in the beginning of the 1980s.   There had been a few cases of homosexual men who developed opportunistic cancers or infections that did not respond to treatment attempts.   AIDS was not yet named.   AIDS was later identified in 1982.There are four main stages that compose HIV infection: â€Å"primary infection, clinically asymptomatic stage, symptomatic HIV infection, and progression from HIV to AIDS† (Adve rt.org). ·Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Primary infection is similar to the flu, with symptoms that are characteristic of the flu virus.   This stage only lasts a few weeks.   During this stage, diagnosis is often missed (Advert.org, 2007) ·Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   The clinically asymptomatic stage can have an average duration of ten years.   There are usually no symptoms during this time.   Antibody tests, however, can be positive for HIV.The viral load test plays an important role in treatment.   It measures the amount of HIV that enters the lymph nodes, where the virus tends to gravitate to (Advert.org, 2007). ·Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   The symptomatic HIV infection stage shows more symptoms.   This is because the immune system has been damaged quite a bit more.   The symptoms can start out weak and become stronger as the immune system deteriorates further.   During this time, many opportunistic infections and cancers appear (Advert.org, 20 07). ·Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   The final stage is the progression from HIV to AIDS.   A person with HIV will be diagnosed with AIDS when they develop a low count of T helper cells.   They may also be diagnosed with AIDS if they have several opportunistic infections or cancers (Advert.org).The symptoms of AIDS can vary.   Most symptoms are caused by infections.   Many are similar to the flu virus, such as fever, chills, and weakness.   Major pulmonary illnesses that can occur are pneumocystis pneumonia and tuberculosis.Major gastrointestinal illnesses that can occur are esophagitis and chronic diarrhea.   Major neurological illnesses that can occur are toxoplasmosis, which infects the brain, eyes, or lungs, progressive multifocal leukoencephalopathy (PML), which causes nerve impulse impairment, AIDS dementia complex (ADC), and cryptoccal meningitis, which can be fatal if not treated (Wikipedia Online Encyclopedia, 2007).Major opportunistic cancers occur in peopl e with HIV, and almost always signal progression to AIDS.   The following malignant cancers can lead to an AIDS diagnosis: ·Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Kaposi’s sarcoma – the most common type of tumor found in HIV+ people; affects the skin, mouth, lungs, and gastrointestinal tract ·Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   B-cell lymphomas – the presence of these cancers almost guarantees a person has progressed to AIDS ·Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Cervical cancer – In women with HIV, this cancer is caused by the human papilloma virus (HPV)With a weakened immune system, HIV+ people can also develop a large amount of infections that can be bacterial, fungal, parasitic, or viral in nature.   The following are descriptions of some of the possibilities, provided by MayoClinic.org (2006):

Week1 Idv Essay examples

Week1 Idv Essay examples Week1 Idv Essay examples Current Events in Business Research Crystal Perez RES/351 May 30, 2015 Albert Smothers Current Events in Business Research The business research process begins with collection of data and then processed into information that can be used to define more details on where, when, how, and what type of business is needed for that type of section. When deciding to start my own business with Scentsy I had to first collect data as to what the company was that I was getting into. Then I had to decide if I like the product that was being sold enough to sell it myself. The next variable would be whether or not people would buy it and if I would have continued product sales. The methods for this company sell best by word of mouth and my group parties. The empirically testable hypotheses in this case are that other people are selling the product and are doing great at it. This company is growing at such a fast rate that the people that involve themselves into it will be guaranteed to make nice amounts of money from a great product and business plan. When competing with other type of businesses they have a unique product that will not burn skin, and they have a one of a kind product that no one else has. Statistically the products are safer than party-light because there is no open flame Scentsy uses only a light bulb to heat and release the fragrance. It is proven that candles left unattended can cause a fire. While Scentsy only uses a light bulb this can be a drawl back for

For Family and Friends Essay Example

For Family and Friends Essay Example For Family and Friends Essay For Family and Friends Essay We all know that thanksgiving isn’t only about the food. It is also about the things you are thankful for having in life. I am so thankful for family, friends, and nature. These things are all I need. I am thankful to have what everybody has, needs, or wants. Life wouldn’t be the same without it. My life is perfect right now thanks to my family, friends, and nature. The first thing I am thankful for is having my family. They are always here for me. Where every I am, whatever I do, and whatever things I get myself into. My family is the number one thing in my life. They come before anything else. If I didn’t have them, I don’t know where I would be now. I have two older sisters, one older brother, and one younger brother. I enjoy them around me a lot. They make my day when it is down. They know exactly when something is wrong with me. I also have two older brother-in-laws and one older sister-in-law. My sister-in-law is really nice to me. She gets me everything I need. My second older sister has a daughter. She is so cute. She makes my day also because the thing she does is really funny. : I really love my family more than anything. The second thing I am thankful for is having friends at school. When I am down at school, they don’t know, but still manage to put a smile on my face or make me laugh. I also like hanging out with them to get everything out of my head. When I’m with them, all I think about is how fun it is to be around them. I only have close friends. I don’t have any best friends. The thing I love most about having good friends is that I know they have my back where ever and whenever. I will always go to my friends if I am down. I love my friends. The third thing I am thankful for is nature. Without nature I wouldn’t be born. I appreciate everything in life. I like how everything in this universe is so nice. I like how we can breathe the air we breathe. I really don’t like how people aren’t thankful to have such a place to live on. They throw trash on the floor. They waste water. They do all the stuff that harms nature. I don’t litter. I don’t waste water. I really care about our planet because I think it might be the only one we will have. I think people should learn how to recycle and throw their own trash away and maybe sometimes help pick up trash. I am really thankful to have nature. So there are a lot more things I am thankful for but these are the top three reasons I am thankful for most. These are important to me because they bare almost everything I have and I would hate to lose them. Life wouldn’t be the same without these three topics. Maybe you are thankful for the same reason as I am, but we’ll never know. You should write an essay stating the things you are thankful for.

How to Search for Files and Folders With Delphi

How to Search for Files and Folders With Delphi When looking for files, it is often useful and necessary to search through subfolders. Here, see how to use Delphis strength to create a simple, but powerful, find-all-matching-files project. File/Folder Mask SearchProject The following project not only lets you search for files through subfolders, but it also lets you easily determine file attributes, such as Name, Size, Modification Date, etc. so  you can see when to invoke the File Properties Dialog from the Windows Explorer. In particular, it demonstrates how to recursively search through subfolders and assemble a list of files that match a certain file mask. The technique of recursion is defined as a routine that calls itself in the middle of its code. In order to understand the code in the project, we have to familiarize ourselves with the next three methods defined in the SysUtils unit: FindFirst, FindNext, and FindClose. FindFirst function FindFirst(const Path: string; Attr: Integer; var Rec: TSearchRec): Integer; FindFirst is the initialization call to start a detailed file search procedure using Windows API calls. The search looks for files that match the Path specifier. The Path usually includes wildcard characters (* and ?). Attr parameter contains combinations of file attributes to control the search. The file attribute constants recognized in Attr are: faAnyFile (any file), faDirectory (directories), faReadOnly (read only files), faHidden (hidden files), faArchive (archive files), faSysFile (system files) and faVolumeID (volume ID files). If FindFirst finds one or more matching files it returns 0 (or an error code for failure, usually 18) and fills in the Rec with information about the first matching file. In order to continue the search, we have to use the same TSearcRec record and pass it to the FindNext function. When the search is completed the FindClose procedure must be called to free internal Windows resources. The TSearchRec is a record defined as: typeTSearchRec record Time: Integer; Size: Integer; Attr: Integer; Name: TFileName; ExcludeAttr: Integer; FindHandle: THandle; FindData: TWin32FindData; end; When the first file is found the Rec parameter is filled, and the following fields (values) can be used by your project.. Attr, the files attributes as described above.. Name holds a string that represents a file name, without path information. Size in bytes of the file found.. Time stores the files modification date and time as a file date.. FindData contains additional information such as the file creation time, last access time, and both the long and short file names. FindNext function FindNext(var Rec: TSearchRec): Integer; The FindNext function is the second step in the detailed file search procedure. You have to pass the same search record (Rec) that has been created by the call to FindFirst. The return value from FindNext is zero for success or an error code for any error. FindClose procedure FindClose(var Rec: TSearchRec) ; This procedure is the required termination call for a FindFirst/FindNext. Recursive File Mask Matching Searching in Delphi This is the Searching for files project as it appears at run time. The most important components on the form are two edit boxes, one list box, a checkbox and a button. Edit boxes are used to specify the path you want to search in and a file mask. Found files are displayed in the List box and if the checkbox is checked then all subfolders are scanned for matching files. Below is the small code snippet from the project, just to show that searching for files with Delphi is as easy as can be: procedure FileSearch(const PathName, FileName : string) ;var Rec : TSearchRec;Path : string;begin Path : IncludeTrailingPathDelimiter(PathName) ; if FindFirst (Path FileName, faAnyFile - faDirectory, Rec) 0 thentryrepeat ListBox1.Items.Add(Path Rec.Name) ; until FindNext(Rec) 0;finally FindClose(Rec) ; end;...{all the code, particularly recursivefunction call can be found (downloaded) inthe project source code}...end;

(SOCIAL WORK) Social Circumstances Report - Case Study Essay

(SOCIAL WORK) Social Circumstances Report - Case Study - Essay Example She likes to spend time with her grandmother and learn Gujarati from her. Till this age she has not dated or selected her lover. She comes from a conservative family background. In their family culture they respect Muslim traditions and follow their customs. Ruksana suffers from certain disabilities like learning disability and physical weakness. Many people in the world faced this problem in their childhood. â€Å"Learning disabilities are problems that affect the brains ability to receive process, analyze, or store information.† (Learning disabilities 2009). Her speech is impaired and she struggles due to phonological disorder. These two problem forces her to take help from others in her personal chores. She travels short distance by electric wheelchair. She completed her schooling from a residential specialist school. Students of such schools are different from normal students. They cannot learn like normal students. They are physically weak and have learning disability. According to a report about safeguarding disabled children in residential special schools â€Å"protection from abuse of disabled children living in residential settings has received much less attention than the protection of children looked after by local authorities.† (Paul, Cawson & Paton 2006). People need patience to communicate with her. It indicates that one reason for her impaired speech may be lack of attention from her parents or other close relatives. Had they given more attention to her in her childhood, this problem could have been solved to an extent. Her speech and language therapist Mr. Jean helps her for this. He adopts computerized assistive voice technology and she is interested in this computer based study. Usually such people seek help from learning and speech therapists when they face problem in learning and reading (About academic language therapy 2004). Here Ruksana did not get help at the initial stage. When she got such a

Professional Learning Communities Assignment Example | Topics and Well Written Essays - 1250 words

Professional Learning Communities - Assignment Example n ongoing, job-embedded; results driven and a professional development model that fosters collegiality and collaboration among the entire education setting. Alternatively, the intellectual goal of the mission was attained by contributing to some of the existing research bodies, which informs regarding the professional development practices (Baccellieri, 2010). Before implementing the process, the school had to communicate its vision first. In this case, individuals involved had to begin developing a shared vision that was grounded towards mutual understanding and trust. The vision in this case was supposed to be important while making important decisions regarding the learning institution. Alternatively, the vision was to show commitment of the school in attaining long-term objectives (Baccellieri, 2010). Therefore, the first step during the implementation process was to have a belief thus, how the school members were seeing the world, capabilities and skills that are conducive to the change. The principle of the school advocated for a person-centered type of approach especially towards the staff management. Alternatively, the development of the teachers became a priority. The second approach during the implementation process was building the relationships between the learners and the teachers. The focus in this case was the cognitive dimensions regarding the staff’s job (Buffum, 2009). The relationships were also built through recreational ways. Most of the activities done here were instrumental in building an effective atmosphere of trust among the members of the institution. After building the relationship between the members of the institution, the third principle during the implementation process was empowerment. In this case, the process entailed enabling the students, staff and the parents into participation and the contribution of emerging expertise for the benefit of the institution. In doing this, several circulating logistical information systems

THE VARIOUS TYPES OF SPREADSHEET PROGRAMS Essay

THE VARIOUS TYPES OF SPREADSHEET PROGRAMS - Essay Example The success or failure of a business institution depends solely on the way it handles accounting. Accounting systems are responsible for analyzing and monitoring the financial condition of companies, preparation of documents necessary for tax purposes, providing information support to many other organizational functions, and so on. The origin of spreadsheets is primarily in the context of accounting applications having major uses with cashflow analysis, budgeting and planning. Its origins began primarily in the context of accountancy applications, which to this day still represent one of the spreadsheets major uses with cashflow analysis, budgeting and planning typical of such applications. Indeed, despite its versatility and use across a range of academic disciplines, the spreadsheet is largely viewed as a business tool with applications covering general administration, sales and marketing, manpower analysis, resource allocation, operational analysis and strategic planning, to name a few [2]. The spreadsheets are used both by highly skilled specialists to generate complex business reports as well as by beginners for routine low-level applications who are unaware of the real potential of spreadsheets. Earlier research by Pemberton and Robson (1995) concluded that, while the spreadsheet has become a natural feature of the business landscape, extent of usage is only one, albeit limited, performance measure with which to illustrate spreadsheet proliferation in business. In many cases, claims of expertise revolve around only the simplest of features, often at the lower end of the skills hierarchy [3]. Evolution of spreadsheets: Spreadsheets came into market in 1979 with the introduction of VisiCalc, the software allowing personal computer users the flexibility to perform simple operations without recourse to a mainframe computer. However, the specific term â€Å"spreadsheet† dates back with its earliest

International Marketing Plan for Monmouth Coffee House Essay

International Marketing Plan for Monmouth Coffee House - Essay Example Monmouth will open its first coffee house in Colombo, which is the capital city of Sri Lanka. This investment decision was made after considering the geographic, legal, political, economic, natural and cultural aspects as well as the competitiveness of the potential market. Formally known as the Democratic Socialist Republic of Sri Lanka, Sri Lanka is located south of India, on an Island in the Indian Ocean. The Countries economic backbone is agriculture, but industry and services sectors also play a big role in the economy. Colombo, the city that has been selected as the starting point for Monmouth’s business, is largely a commercial capital, where several foreign based organizations have operations. The country’s scenic beaches, historical sites, and tropical climate are quite popular with tourists. The booming tourism industry has prompted the development of infrastructure, and this invariably provides a good business opportunity for a small organization such as Monm outh. Sri Lanka’s resources include gemstones, limestone, mica, graphite, quartz, slate and industrial clays. The country is also a key producer of extracted minerals and cash crops that include tobacco, tea, rubber, and coconut. Coffee is also available in the country, but the supply is quite low (Reddy 2003). Hence it is important for Monmouth to consider the issue of finding a reliable local or foreign supplier in its logistics planning. The city of Colombo is relatively easy to reach and navigate through due to its efficient transportation network. Most residents of Colombo and Sri Lanka as a whole rely on radio as the main tool of mass communication. Television is also used by a large percentage of the country’s population. There are also three daily newspapers published in Sri Lanka (Cummings 2007). Hence, Monmouth will use the three media tools used in the country for advertising purposes. Culture Culture is one of the most important factors to consider when ven turing into a new market. Individual cultures are constantly being shaped by different variables such as values, attitudes, religion, manners and attitudes, aesthetics, norms and customs, social institutions, technology and education. Official records indicate that there are roughly 20 million Sri Lankans who mainly come from the Tamil and Sinhalese ethnic groups. Both Sinhala and Tamil are used as the national and official languages of Sri Lanka. English is spoken mainly in urban areas including Colombo, as the second language. The city has a population of about 2 million people. Many of these people are

Tear the Curtain Essay Example | Topics and Well Written Essays - 750 words

Tear the Curtain - Essay Example Alex is a Vancouver theater critic and is very passionate about his work. He firmly believes he found the legendary theater director Stanley Lee who directed the famous (or infamous) ‘The Empty Space’. Alex is strong in his conviction that Stanley Lee is the person who can destroy audience complacency, as he is not satisfied with the way the theater business is progressing. But what Alex is trying to do is not easy. He strives to prove something through Stanley Lee but himself gets caught up between two mob families and the Empty Space Society. The breakdown of Alex has a buildup revolving around Stanley Theatre. The two rival gangs are trying to take control of this theater and Alex gets caught up in the crossfire (Kaplan, 2012). Anagnorisis occurs in the play when Alex creates confusion among the audience about reality and truth. For a moment the audience gets puzzled if they are watching a play or is it happening in real life, or probably they too are the part of a play. This strange sense of existence or the question of existence seeds catharsis in the audience. Although the plot of the play doesn’t revolve around Rene Decarte’s philosophy of existence yet there are aspects in the play that leave a deep impact on the audience, the make them question their own existence. This conflict leads them to a catharsis, where they ask quick question to their own ‘self’ to confirm if they really exist in the audience or are they on s stage. But this form of questioning is overshadowed by the strong premise that they bought the tickets to the play and that can’t be a part of the play. They have their lives back at home, their own sense of existence. How can that be true that Alex is reading the script and the script itself reads he is reading it? It is there and then the audiences get wrinkles on their foreheads, some start scratching their chins, while some would look away from the stage to

Women and men are encouraged to behave according to specific gender Essay

Women and men are encouraged to behave according to specific gender patterns, critically discuss this assertion by reporting on evidence from your collected sou - Essay Example Typically, men hold positions of power even in democracies. Only 14 percent of the countries have achieved 30 percent representation of women in the parliament, as set out in the Beijing Declaration on Women in 1995. Women have less access to and control of economic powers, rewarded for less remuneration than men for the same work, treated differently in global trade. Women receive less education than men; have to walk long distances to collect drinking water in poorer countries, thereby falling vulnerable to violence; sexual and reproductive health problems result in illness and disability to women; more number of women being victims of HIV/AIDS because of restrictions on women being able to practice safe sex and having access to HIV testing and care services; women become victims of gender-based violence and cultural taboos. On the whole, the mainstreaming of gender has generally failed because the approach towards 'integrating' women in the society does not challenge existing powe r equations. Women have continued to be offered stereotyped jobs, not receiving equal training and education and insufficient resources for women's mainstreaming (Oxfam). With globalization, the traditional economic relationships, including gender relationships, are crumbling down. The classical patriarchy, dependent on the male property ownership and family headship notion, had given rise to the urban "fordist gender regime" - male bread earner/ female house maker - in the western world in the 1950s and 1960s, also duplicated in some parts of the developing world. Economic development and increased competition has meant that the male salary earnings are not sufficient for the increasing consumption patterns. Brenner (2003) notes that incorporation of women in the workforce and their increased access to education and literacy has brought feminism in the forefront of organized politics (cited in Dhawan, p2). Women activists are not increasingly becoming more vocal in national politics but also on global issues. At the same time, marginalized women are becoming even more vulnerable to global capital reorganization. Worldwide, women are facing the brunt of longer working hours, impoverishment, economic insecurity and forced migration and urbanization. Working class women find themselves in the crossroad of development and reactionary policy and continue to remain, if not become increasingly so, victims of fundamentalism, economic insecurity and a complex web of power relations (Kaplan, 1999, cited in Dhawan, p3). Pressures of structural adjustments imposed on many Third World countries have given rise to fundamentalism, which stem from the traditional patriarchal powers and victimize women even more. The emerging capitalist structures of many of these societies have eroded the protection of the traditional patriarchy that women used to have earlier. Women in the Third World are at the crosshead of two powerful forces: one, the nationalist agenda that is inherently masculine in which women are expected to follow traditional roles while the men are free to participate in the political arena, and two, global capital, which forces wom en to participate in the economic field, overpowering the nationalist agenda. While in the west, women of color feel that the feminist agenda is essentially white-oriented, in the Third World, the political interests of working class women are marginalized. Over and above this, women from the

Tear the Curtain Essay Example | Topics and Well Written Essays - 750 words

Tear the Curtain - Essay Example Alex is a Vancouver theater critic and is very passionate about his work. He firmly believes he found the legendary theater director Stanley Lee who directed the famous (or infamous) ‘The Empty Space’. Alex is strong in his conviction that Stanley Lee is the person who can destroy audience complacency, as he is not satisfied with the way the theater business is progressing. But what Alex is trying to do is not easy. He strives to prove something through Stanley Lee but himself gets caught up between two mob families and the Empty Space Society. The breakdown of Alex has a buildup revolving around Stanley Theatre. The two rival gangs are trying to take control of this theater and Alex gets caught up in the crossfire (Kaplan, 2012). Anagnorisis occurs in the play when Alex creates confusion among the audience about reality and truth. For a moment the audience gets puzzled if they are watching a play or is it happening in real life, or probably they too are the part of a play. This strange sense of existence or the question of existence seeds catharsis in the audience. Although the plot of the play doesn’t revolve around Rene Decarte’s philosophy of existence yet there are aspects in the play that leave a deep impact on the audience, the make them question their own existence. This conflict leads them to a catharsis, where they ask quick question to their own ‘self’ to confirm if they really exist in the audience or are they on s stage. But this form of questioning is overshadowed by the strong premise that they bought the tickets to the play and that can’t be a part of the play. They have their lives back at home, their own sense of existence. How can that be true that Alex is reading the script and the script itself reads he is reading it? It is there and then the audiences get wrinkles on their foreheads, some start scratching their chins, while some would look away from the stage to

Ethics and Law Coursework Example | Topics and Well Written Essays - 500 words

Ethics and Law - Coursework Example According to Williams, law includes the codes of conducts that are developed and made obligatory by the authority for every member of the society or a particular group, state or community (p 51). The state sets punishments that are meted on individuals who contravene the codes of conduct. Laws are supposed to be adhered to regardless of their ethical connotation. A law abiding citizen enjoys his/her freedom regardless of whether the laws are suppressive. In other words, development of state laws is independent of the ethics. Ethics on the other hand is concerned with human behavior. It is about how people conduct themselves in the presence or absence of others. Tingle and Cribb view ethics as the moral values against which humans evaluate behavior (p 66). Generally, humans evaluate ethical behavior on the basis of doing to others what they would like to be done to them. This means that if a person hurts another, that is unethical because he/she would not like the same to occur to him /her. In contrast, the law seeks to protect the rights of individuals and the general public based on a common understanding of what is good for them. For example, a government sets laws to protect the rights and freedoms of its citizens, which may not be granted in another state. An officer in the public service is a servant of the state and hence the government. He/she is required to demonstrate professional ethics while undertaking his/her duties. On the other hand, he is obligated to the statutory duties that surpass his/her moral background. He/she is supposed to perform his/her duties according to the laws that govern the particular field. For example in some states, a parent who is convicted of dealing or using illegal drugs is denied parenting rights. The child or children are adopted as the parent serves the prison sentence. The judge who takes away parenting rights is guided by the

Gender Identity Paper Essay Example for Free

Gender Identity Paper Essay The determination of gender identity is much deeper than whether a person is born a male or a female. The exact identifier that separates gender identity is currently unknown but researchers believe that genetics, hormones, reproductive organs, biological, and environmental factors all play a role in distinguishing a person’s gender identity. A person’s physical gender and their sense of gender are formed at two different times in two different parts of the body. A person’s gender is whether they are born male or female, but the way they identify themselves may be the opposite, which is not uncommon and has occurred since the beginning of time. In culture males are known to be the stronger, more aggressive sex, while females are the fairer, more nurturing sex. Usually, by the age of four, individuals have identified their gender identities aside from what gender they were born as physically. Throughout this paper, I will discuss the biological factors of gender identity (nature), environmental factors (nurture), and the role between hormones and behavior, and how these interactions all affect the determination of one’s gender identity. Gender identification begins to develop while the fetus is in the beginning stages of development. Between weeks six and twelve of gestation is when the fetus begins developing reproductive organs and that is when the fetus takes on the role of male or female. Hormones are produced in both the nervous system and the endocrine system and are transported through the blood stream. Specifically, hormones are chemicals that combine and respond to certain cell receptors. Hormones like testosterone and androgen are mainly found in the male gender while estrogen is mainly found in the female gender. Testosterone is a contributing factor to behaviors like aggression. â€Å"Gender identity, an individual’s self-awareness of maleness or femaleness, and gender role, are programmed for the child within his mother’s womb,† (Institute of Medicine, 2006). Evidence has shown that the female gender is likely to excel in verbal skills and muscular coordination when their production of estrogen is high rather than when it is low. For men, they are stronger and more aggressive when their testosterone levels are high and they are able to perform better in actions that require physical performance. The nature side of the theory relies on prenatal hormones that modify the brain and peripheral tissue and the development of male or female external genitalia. Although a person may have a certain physical gender, their gender role is the adoption of masculine or feminine behavioral traits that are appropriate for that specific sex. Gender identity differs from the gender role because it is an individual’s personal sense of sex, which is not necessarily their physical gender. There are multiple stages from childhood to adulthood when hormones are present that are identifiable of a specific gender. The pituitary gland (or hypophysis) secretes many hormones during puberty including adrenocorticotropic hormones, growth hormones, gonadotrophins, prolactin, and thyroid stimulating hormones. Gonadotrophins, which include luteinizing and follicle stimulating hormones, stimulate sex hormone production in the ovaries or testes and also lead to egg and sperm maturity. Prolactin stimulates milk production and adrenocorticotropic hormones stimulate the adrenal glands to secrete steroid hormones like cortisol. All of these hormones play a major role in sexual development and an individual’s determination of gender identity. Environmental factors of gender identity arise as soon as the individual is born. Everything from a female child wearing a pink dress to a male child having a sports themed blanket can play a role in their gender identity. Sociologists believe that by the age of five years old, females show a preference for dolls, arts and crafts, and playing dress up while males prefer cars, blocks, tools, and outdoor play. â€Å"The environment has a direct relation to personality traits, because characteristic adaptations are always involved in expression,† (Nature over Nurture, 2000). At a young age, children who are taught that traits and activities are appropriate or inappropriate for them to perform because of their gender tend to absorb those teachings and are influenced by them later in life. For example, young girls who are raised believing boys are innately better at sports than girls, may disclaim their interest in sports and go on to believe they are not good at them without pract icing them to their full potential. Both males and females have proven to be great athletes but if at a young age, a girl is told she will never be as good as a boy she may never give sports and athleticism a chance. Young children learn by observations, if a young girl witnesses her mother performing the acts of a man then she will repeat those acts and believe that is what is appropriate for her. The same goes for the male gender, if a little boy observes his father doing something that a woman is more likely to do like sewing or interior decorating then that is what the little boy will believe is expected of him upon adulthood. â€Å"For instance, the way in which one educates children, how children in institutions such as orphanages are raised, and the kinds of day-care are considered optimal have all been influenced by one’s understanding of the interaction of biology and environment regarding gender identity,† (Kowalski Westen, 2005). The previous statement is very true because children observe many things that one may never think would make any difference but in reality they do. Nature factors include everything from what kind of parents raise the child, what roles they perform, the culture, and even the color of paint on the child’s walls all make a difference in the child’s personal gender identity. I believe that between nature and nurture and their influence on gender identity, nature has a greater influence. For example, if a perfectly healthy little girl with no hormone disorders is raised with a single father and only brothers with no immediate influence of females, she is more likely to become a tomboy and take on the gender identity that resembles that of her father’s or brothers’. The same reference goes for a boy raised with a single mother and only sisters with no immediate influence of a male figure in his life. Matthew Wolfe-Meyer makes a valid point when saying, â€Å"nature and its contestation is a dominant strategy†¦ unfortunately nurture fails to receive similar scrutiny and culture is more often used as an explanatory device than deeply interrogated for its logistics.† Often times when a child is going through puberty and takes on the role of the opposite gender, many people jump to the hypothesis that there may be something wrong with their hormones or a chemical imbalance but before jumping to that conclusion, they should look at their home life, how was the child raised, what was their environment like and from there they will find many answers. All children naturally comply with the demands of their internal sense of gender without effort. If the child becomes confused with their gender then they often refer to behaviors of adults near them and they learn what actions are appropriate for them relatively quick. Environmental factors bear a critical amount of effectiveness in gender identity but because environmental factors are ever changing, it proves that the nurture theory is a substantial factor. Currently, psychologists and researchers do not know the exact causes of gender identity and individuals taking on the opposite roles. But there are many factors that support both sides of the nature versus nurture argument. The male and female genders each have differences in many areas both physical and emotional but neither is â€Å"better† than the other. By the age of four years old each child already has an idea of who they are and what gender they belong to. Gender confusion is normal but most children are able to look at parents or acting influences in their lives and see what the appropriate actions are for their gender. Nature versus nurture has and will continue to be a strong argument. References: McCrae, R. R., Costa, P. r., Ostendorf, F., Angleitner, A., HÃ…â„¢ebà ­Ã„ kovà ¡, M., Avia, M. D., Smith, P. B. (2000). Nature over nurture: Temperament, personality, and life span development. Journal Of Personality And Social Psychology, 78(1), 173-186. doi:10.1037/0022-3514.78.1.173 Matthew Wolf-Meyer. (2007). Complexities: Beyond nature and nurture. Anthropologica, 49(2), 325-327. Retrieved from http://search.proquest.com/docview/214174663?accountid=35812 Money, J. (1971). Differentiation of gender identity and gender role. Psychiatric Annals, 1(4), 32-37,42-43,8-9. Retrieved from http://search.proquest.com/docview/894195162?accountid=35812 (2006). Institute of medicine (us) committee on assessing interactions among social, behavioral, and genetic factors in health. Washington DC: National Academies Press (US). Retrieved from http://www.ncbi.nlm.nih.gov/books/NBK19934/

The Manufacturing Of DNA Vaccines

The Manufacturing Of DNA Vaccines A detailed design and layout of the facility for the manufacturing of DNA vaccines was developed. The factors foremost in the design and layout of the DNA vaccines facility were compliance to current good manufacturing practices (cGMP), regulatory guidelines, health, safety and environment, effective production, optimum material and personnel flow, effective cleanliness, minimisation of contamination and enhance maintenance. The total site area is 108m X 91m (9828m2) and plant/production area is 32m X 20m (640m2) with space for future expansion. To reduce the impact of airborne particles, relative humidity, pressure and temperature on the purity, efficacy, and safety DNA vaccines product, a containment/cleanrooms of class 100 was design with controlled-air environment with access via airlock, HVAC and high efficiency particulate air (HEPA) filters. In order to conform and comply to current good manufacturing practices (cGMP) and regulations, the following key component of cGMP were i ncorporated into the design, validation master plan (VMP), standard operating procedures (SOPs), appropriate quality control (QC), cleaning-in-place (CIP), sterilisation-in-place (SIP), trained personnel, documentation, health, safety and environment, utilities required and waste treatment process. The entire project timeline was estimated with the aid of Gantt chart project management technique to be a year and 4.5 months with reference to literatures on similar projects. 1.1 Introduction The demand for DNA vaccines for gene therapy, vaccination and for the treatment of diseases such as cancer, malaria, swine flu, HIV, melanoma, etc. is on the increase (Prather et al., 2003; Williams et al., 2009). This is because DNA vaccines triggers cellular and humoral immune responses, safe and stable (Prather et al., 2003). Therefore, there is need to design manufacturing facility for DNA vaccines production to meet the rising demand. However, the design, operations and layout of the manufacturing facility must conform and comply to standards, specifications and guidelines stipulated by regulatory authorities such as the U.S. Food and Drug Administration (FDA), Medicines and Healthcare products Regulatory Agency (MHRA), European Medicines Evaluation Agency (EMEA), World Health Organisation (WHO) and the regulation of the country in which the facility is to be constructed. In addition to meeting this regulations and guidelines the DNA vaccines production process, design and premi ses of its manufacture must conform to good design practices (GDP) and current good manufacturing practices (cGMP) (Shamlou, 2003; Przybylowski et al., 2007). The commercial scale production of DNA vaccines is justified by economics/cost, health, safety and environment, compliance to legal standards and production under Good Manufacturing Practices (GMP) (Shamlou, 2003). This is to ensure that manufacturing processes are controlled and performed according to design specifications and operational procedures in order to ensure that quality is built into the product (DNA vaccines) to assure safety, efficacy, purity and identity consistently (Przybylowski et al., 2007). In addition, GMP requirements are open ended, however the International Society of Pharmaceutical Engineers (ISPE) has enumerated the principal steps to current GMP which include standard operational procedures (SOPs), qualification and validation of process performance, design, quality control testing, adequate process control, sterilization in place (SIP), cleaning in place (CIP), layout design, quality management, documentation and audit of facility as necessary to ensuring specification and maintenance of product identity and compliance to regulations (WHO, FDA, MHRA, etc.) and current good manufacturing practices (cGMP) (Day, 2004). The issue of location for the manufacturing facility is crucial to its profitability as it is influenced by raw material supply, transportation, utilities, environmental impact, waste disposal, local community considerations, personnel, climate, plant size and availability of land (Sinnott, 2005). Moreover, before the design and installation of a new facility for pharmaceutical and biopharmaceutical product manufacture, an environmental impact assessment (EIA) is perform and approved (Davda, 2004). Hitherto, the design of any manufacturing facility must integrate the design of a treatment process and safe disposal of the waste generated to specified legal standards by regulatory authorities and eliminate/minimise harm to health and safety of personnel, environment and product contamination. The manufacturing facility layout must be designed to aid good raw material flow, waste flow and personnel flow around the factory to reduce risk, cross contamination and ensure that production ac tivities and factory operations are performed smoothly and follow a defined procedure. The pharmaceutical manufacturing process must be conducted in clean environment and clean rooms in which the temperature, pressure, air borne particles and relative humidity are controlled to specified conditions by regulators (U.S. FDA, WHO, ISO, MHRA, etc). All these are the component of current Good Manufacturing Practices (cGMP) to build quality assurance, consistency and safety of therapeutic product (DNA vaccines) to human life (Signore and Terry, 2008). The entire operations and activity should be performed by trained and competent personnel and quality management for a satisfactory quality assurance (QA/QC). 1.2 Aims and objectives 1. The defined goal of this project is to develop a detailed design and layout of a manufacturing facility for the production of DNA vaccines for commercial scale, applying current Good Manufacturing Practices (cGMP) and in compliance to regulatory guideline (FDA, FDA, MHRA, WHO, etc.). 2. Provide detail methods for qualification and validation of the design and layout, performance, quality control and enumerate the personnel/staff involved in the project. 3. Estimate the timeline of the project. 2.1 Process overview DNA vaccines production mainly starts on a bench scale through pilot scale to large scale production (Ferreira et al., 2000; Bequette et al., 2004). The design of a large scale facility for the manufacturing of DNA vaccines involves the selection of suitable plasmid DNA constructs/vectors (ColE1-type vectors, pUC vectors, pBR322 plasmid vector, etc.) that will replicate at high copy numbers, the production microorganism cell bank (Escherichia Coli), subsequently followed by fermentation process in the bioreactor under optimum conditions and control media (temperature, pH, pressure, etc.) to maximise cell growth, cell lysis to break the cells to release the DNA, isolation by precipitation of genomic DNA, cell debris, proteins and RNA, purification by anion exchange chromatographic technique because DNA is negatively charged, formulation and blending, sterile filling, packaging and storage in the fridge (Ferreira et al., 2000; Prather et al., 2003; Przybylowski et al., 2007).   2.2 Design of flowsheet The conceptual design of the process flowsheet for DNA vaccines production under cGMP was based on the knowledge of the process block diagram in Fig.1 above and the performance of the associated unit operations. The process flowsheet shown in Fig.2 is interconnection of the various unit operations, fermentation, the downstream processing (cell lysis, precipitation, clarification and concentration, primary purification (anion-exchange chromatography) and secondary purification (size exclusion chromatography)) and blending and formulation of the bulk product into usable form (Prazeres and Ferreira, 2004). Each pieces of equipment in the process flow sheet are designed to conform and comply with standard and code of practice of either International Organisation for Standardization (ISO), British Standard Institution (BSI), American Petroleum Institute (API), American Society for Testing Materials (ASTM), American National Standard Institution (ANSI), etc. to ensure safety, selection of suitable material of construction, and also equipment manufacturers work to produce facilities according to standardized design and size (Sinnott, 2005). Also each pieces of equipment are hygienically designed with good polished surfaces and piping for easy CIP and SIP, elimination of dead zones and sharp edges to avoid microbial growth and contamination and constructed with stainless steel material to eliminate contamination. The final product DNA vaccines are sterilely filled into vials and stored at -20oC in the freezer (Przybylowski et al., 2007). 3.1 Site layout design The site layout was designed to prevent product contamination, environmental pollution and to safeguard the health and safety of personnel. The various unit operations shown on the process flowsheet in Fig.2 and the ancillary buildings required to support the manufacturing facility for DNA vaccine production are laid out to give an economical flow of raw materials to final product storage, flow of personnel and waste around the production site to conform to good manufacturing practice (GMP), reduce risk and product contamination (Sinnott, 2005; Signore and Terry, 2008). The site layout design in Fig.3 was done with consideration to future expansion of the DNA production. Clean rooms, waste treatment area, hazardous process and raw materials were isolated and arranged for safety of product, personnel and environment. The size of the site is 108m X 91m (9828m2) as shown in Fig.3 and the ancillary buildings and support services required for the manufacturing facility are: Storages for raw materials and DNA vaccines. Quality control laboratory. Maintenance workshops and warehouse. Utilities: steam, compressed air, power generation, refrigeration, water (WFI), CO2, N2 etc. Cleaning-in-place (CIP) and Sterilisation-in-place (SIP). Effluent treatment and disposal plant. Process control room Administrative offices Fire stations and other emergency services Amenities required include: roads and car parks, first aid centre, canteen, security, rest room, changing room, training room and visitors centre. 3.2 Facility layout design The detailed design and layout of the DNA vaccines production rooms and equipment is designed to minimise risk, reduce cross contamination, permit effective cleaning and sterilisation of external and internal surfaces of process equipment by the use of clean in place (CIP) and sterilisation in place (SIP), enhance maintenance and control of clean rooms temperature, pressure and relative humidity (RH) under standard operating procedures (SOPs) (Przybylowski et al., 2007). The facility layout design also considered the cleanrooms, equipment and the flow of materials and personnel as key factors that impact on manufacturing cost, operational procedures and productivity (Drira et al., 2007). The DNA vaccines manufacturing facility layout design is 32m X 20m (640m2) in size as shown in Fig.4 to ensure efficiency and safety of the production environment and manufacturing process which are dependent on the layout of the facility (Jacobson et al., 2002). 3.2.1 Cleanrooms/containment design One of the principles of GMP is cleanliness and aseptic operations to prevent product contamination by microorganisms, particulate generated during plant operations and changes in room conditions (temperature, relative humidity, etc.). Therefore, DNA vaccines which are biological drugs are manufactured in clean rooms, that is, a room in which the air quality (airborne particles), the temperature, the pressure and relative humidity are controlled to prevent contamination by impurities, dust and microorganisms in the atmosphere and in the ambient air, in order to protect its purity, efficacy and safety (Sutherland, 2008). The layout and design of the production rooms was according to the International Standards Organisation (ISO) 14644-1 cleanrooms classification shown in Table 2 below. The raw materials, fermentation, purification, blending and formulation and product storage clean rooms are designed for class 100 biosafety cabinet fitted with high efficiency particulate air (HEPA) fi lters and HVAC systems to ensure the entry of clean air into the cleanrooms and exit of dirty air inside the rooms (Sutherland, 2008). The flow of air in and out of the cleanrooms is laminar. Other components of the cleanrooms include: Separate airlocks for entry and exit doors for personnel, raw materials and waste products. An inlet port for fresh purified air. An exit vents fitted with activated carbon filter to purify contaminated air before discharge to ensure environmental safety (Sutherland, 2008). Cleanrooms air pressure is maintained below atmospheric to prevent outward leakage. Nonslip floors, electricity, light appropriate and aseptic processing hood. Humidifiers to maintain and control cleanrooms relative humidity and temperatures 4.1 Raw materials Variations in raw materials composition is known to impact on the quality of DNA vaccines produced and also the operations of the plant. Therefore, raw materials require quality control check before used. The raw materials, reagents and utilities required for the DNA vaccines manufacturing facility are: plasmid DNA vectors, nutrients, glucose, water for injection (WFI), sterile air, salt, buffer capacity (to stabilise pH of fermentation), liquid nitrogen N2, and antibiotic, alkaline, master cell bank (MCB) and working cell banks (WCB). These are placed in the quarantine storage room and undergo quality control testing to ensure that specification are met before used for DNA vaccines production for quality assurance (QA/QC). The flow of materials from the raw materials to the final product (DNA vaccines) is shown in FIG. above and the final DNA vaccines products are stored in a sterile room in a freezer at -20oC (Przybylowski et al., 2007). 4.2 Personnel The compliance to current good manufacturing practices (cGMP) and regulatory guideline depends on people and good management structure. It is essential when developing new facility to integrate all relevant personnel from production, logistics, quality control and engineering in the inception phase of the design and layout. Therefore, for a satisfactory quality assurance of the DNA vaccines production, facility design and layout, the interactions and inputs from various disciplines such as chemists, chemical engineers, biochemical engineers, biologists, microbiologist, pharmacists, civil engineers, project managers, mechanical engineers, electrical engineers, architect, cost engineer and many others are required to carry out defined tasks and responsibilities. The flow of personnel around the designed facility layout during operations is shown in FIG. 4.3 Qualification and validation The qualification and validation of pharmaceutical manufacturing facilities at regular intervals is an integral part of good manufacturing practices (GMP). This is documentary evidence that assures that the DNA vaccines production facility is performing satisfactorily and consistently to specification for the intended purpose (Day, 2004). To do this, a validation master plan (VMP) is drawn up which include: design qualification (DQ), installation qualification (IQ), operational qualification (OQ) and performance qualification (PQ) to confirm that all was done according to specifications (Day, 2004; Chaloner-larsson et al., 1997). However, an internal audit of the facility and instruments is also conducted to ensure compliance and implementation of cGMP and regulatory guidelines. 4.3.1 Design qualification (DQ) Design qualification is carried on the following production pieces of equipment of the manufacturing facility such as bioreactor, centrifuge, anion-exchange chromatography, size exclusion chromatography, microfiltration system, ultra-filtration system, HVAC systems and lyophilizer, for verification and documentation as a prove to show that the equipment designs conforms to regulatory standards such as ISO 9000, BSI, etc. 4.3.2 Installation qualification (IQ) The IQ is a documented verification that confirms that the manufacturing facility layout, HVAC systems, supporting utilities (steam, CIP, SIP, etc.) and process equipment are built and installed in compliance to the designed specification and manufacturers recommendations (Chaloner-Larsson et al., 1997). The IQ document for each equipment/system contains name of equipment/system, description, model and identification number, the location, utility requirements, any safety feature, date, personnel and approver. 4.3.3 Operational qualification (OQ) The OQ is the documentary verification of the manufacturing facility to confirm that each pieces of equipment operates in accordance to designed specifications and operation conditions and will consistently (Day, 2004). This is accomplished by testing control systems, alarms, switches, and providing standard operations procedures (SOPs) for the operations of the manufacturing facility. 4.3.4 Performance qualification (PQ) Performance qualification (PQ) is a documented verification that confirms that the manufacturing facility and the supporting utilities will consistently perform to required specification under the designed operating ranges to production the DNA vaccines. The following systems and pieces of equipment are validated for performance check: purification processes, bioreactor, HVAC systems, autoclave, CIP, SIP, oven, pure steam generation system, purified water and water for injection systems, centrifuge and lyophilizer. 4.4 Quality assurance and Quality control (QA/QC) The consistent production of DNA vaccines to meet therapeutic specification of safety, purity, efficacy and potency depends on good quality assurance and quality control (QA/QC) performed by qualified persons (QP). Quality control of the DNA vaccines is one of the key component of current good manufacturing practices (cGMP) and regulatory guideline of U.S. FDA, WHO, MHRA, ISO 9000 etc. It involves testing procedures employed to check that the DNA vaccines product are uniform from batch-to-batch and raw materials used for its production meet the specification, quality and standard. The quality control testing laboratory consists of the following assays for determining quality of raw materials and product purity, efficacy and safety: High performance liquid chromatography (HPLC) to determine the percentage of RNA, supercoiled and nicked. pH meter test for residual buffer salts and alkaline. Agarose gel electrophoresis (AGE) test for plasmid DNA vaccine purity, determine RNA and genomic DNA presence in the product. Gas chromatography test for the presence of ethanol, determine plasmid size Flame ionization detector (FID) test for the presence of isopropanol in the product. Transfection/Immunofluorescent staining test for potency of plasmid DNA vaccines. Kinetic chromogenic limulus amoebacyte lysate (LAL) test to quantify the presence of endotoxin in the product Sodium dodecylsulfate polyacrylamide gel electrophoresis (SDS-PAGE) test for the quantity of proteins in the product (DNA vaccines). GeneQuant spectrophotometer test to quantify the purity of the DNA vaccines product. Bicinchoninic acid (BCA) assay quantify the amount of proteins present in the bulk product. Mass spectrometer, measuring, weighing, recording and control instruments calibrated regularly. The analytical instruments are validated to ensure performance. The DNA vaccines must meet at least minimum specification, purity, efficacy, safety and quality set by regulatory authority after sterile filling before released (Przybylowski et al., 2007; Prather et al., 2003). 4.4.1 Product testing Prior to the release of the DNA vaccines after blending and formulation, the quality control department must test each batch for purity, identity, efficacy, safety and potency using the analytical assays mentioned above, and if the result does not meet regulatory specifications the batch will not be released (Prazeres and Ferreira, 2004). Table 1 below shows an example of DNA vaccines purity and quality specification. 4.5 Documentation Documentation of all the activities and operations is a key requirement for GMP, regulatory bodies, and helpful for management structure, traceability of every batch history, planning, elimination of errors, effective communication, records keeping and design and layout of the DNA vaccines facility. Regulatory authorities such as FDA, EMEA and WHO require documentary evidence as prove that the DNA vaccines facility will perform consistently in compliance to cGMP. The DNA vaccines project documentation include: standard operational procedures (SOPs), design qualification, installation qualification, facility layout design, specification sheets for each pieces of equipment, performance qualification, quality control records, process flow sheet, site plan, personnel records, licence, commissioning, validation master plan (VMP), packaging, labelling, etc. both on paper and electronically (Signore and Terry, 2008; Sinnott, 2005). 4.6 Utilities Utilities are the support services required for effective design, layout and manufacturing process of DNA vaccines, they include: Potable water, USP purified water used for cleaning in place (CIP) to clean process equipment. Water for injection (WFI) used for media preparation, fermentation media and rinsing of equipment after CIP. Clean steam for sterilisation in place (SIP) to sterilise the process equipment after each batch. Electricity for lightening, instrumentation, analytical instrument, etc. Sterile gases such as filtered sterile air for fermentation process, nitrogen N2 for working cell bank storage, heating, ventilation and air-conditioning (HVAC) system. Refrigeration for the storage of the DNA vaccines product at -20oC. 4.6.1 Heating, Ventilation and Air-Conditioning (HVAC) System Heating, ventilation and air-conditioning (HVAC) system is a component of the production clean rooms design and layout, it plays a vital role in ensuring that the manufactured DNA vaccines product quality, efficacy, safety and purity is not impacted by room temperature, relative humidity (RH), air borne particles, pressure and cross contamination in accordance to standards and classifications of rooms by ISO 14644-1, US Fed. Std. 209, BSS5295, EEC, etc. (Zyl, 2005). The HVAC systems for this manufacturing facility include: High efficiency particulate air (HEPA) filters to control air borne particles, dust and microorganisms of the clean rooms. Desiccant dehumidifiers/refrigerated dehumidifiers are used to monitor and control the temperature and relative humidity (RH) of the rooms in order to comply with raw materials and DNA vaccines product requirement. Airlocks and air handling unit (AHU) are put in place for pressure monitoring, control and maintenance of pressure cascade with the production rooms. 4.6.2 Water and clean steam systems Purified water, water for injection (WFI) and clean steam are essential utilities generated on site and distributed for use in DNA vaccines production, clean-in-place (CIP), sterilisation-in-place (SIP), and media preparation (Robbins, 2010). In order to ensure safety, purity and efficacy of the DNA vaccines the water used for its production is sterile water for injection (WFI). The WFI is produced from purified water by distillation/reverse osmosis to meet the required standard of purity specified by the United State Pharmacopeia (USP) (pH 5.0-7.0, nonpyrogenic and antimicrobial agent). The WFI is stored at elevated temperature (80-95oC) to eliminated microbial growth, and the system constructed with stainless steel to eliminate contamination (Robbins, 2010). The WFI system design is shown in FIG. 4.7 Waste treatment and management The system for treating the waste generate from the DNA vaccines manufacturing facility is an integral part of the design of the facility, layout and good manufacturing practices (GMP). The major waste generate from the production process are genomic DNA of the host cells, RNA, proteins, cell debris, salts, endotoxins and plasmid isoforms (Ferreira et al., 2000). The waste is treated to regulatory standards (BS, ISO, etc.) to avoid harm to health and safety of personnel and environment (HSE), pollution and eliminate cross contamination of the product. The system for treating the waste is illustrated in FIG. below WWWW Incineration Autoclaved Waste Discharge Autoclave 4.7.1 Health, Safety and Environment (HSE) The DNA vaccines production microorganism poses some hazard. The environmental impact assessment (EIA) of the DNA vaccines production system therefore becomes a key part of the design and layout of the manufacturing facility (Prazeres and Ferreira, 2004). However, the environmental impact assessment (EIA) study and the design will require approval from environmental protection agency before the facility is built (Davda, 2004). To ensure that health, safety and environmental regulations are met, the process design and layout is geared towards minimisation of waste generation, safety of product, safety and health of personnel and incorporation of waste treatment process before discharge to the environment. In addition, the personnel will also be provided with personal protective equipment (PPE) such as hand gloves, gowns, goggles, etc. to work with. 4.8 Legislation and regulation The manufacture of DNA vaccines is highly regulated to ensure that it is safe, efficacious and pure for humans, and also its production carried out in accordance to current GMP (Plumb, 2005). Therefore, before the DNA vaccines can be marketed they must be licence from the relevant regulatory bodies such as the Medicines and Healthcare products Regulatory Agency (MHRA) in the United Kingdom, the Food and Drug Administration (FDA) in the United States, the EMEA, WHO and so on (Smith and Dennis, 2001). The manufacturing facility used for the production of the DNA vaccines must be licence too (Plumb, 2005). These licences are obtained if and only if the manufacturing facility design, layout and premises of its manufacture conform and comply to current good manufacturing practices (cGMP) and with regulatory standards, guidelines and specifications stipulated by MHRA, FDA, WHO, EMEA, ISO, etc. Hitherto, the company must also provide detailed documentary evidence about the safety, purity an d efficacy of the DNA vaccines and the consistency of its manufacturing process. Signor and Terry reported that the incorporation of current good manufacturing practices (cGMP) into good design practices (GDP) at the inception of the manufacturing facility will ensure that regulatory conditions are met (Signor and Terry, 2008). The regulatory guidelines specify the requirements for the pharmaceutical manufacturing facility, not the methods to achieving it. The regulatory bodies functions include: safeguard public health, licensing, monitoring DNA vaccines post-marketing, regulating clinical trials and publish quality standards. 5.1 Project timeline This project has a definite start, middle and end, which consist of several activities ranging from the environmental impact assessment and design approval, construction to commissioning executed in a defined order to bring the project to completion. It is the function of the project manager to plan, schedule and control these tasks/activities in a specified sequence and allocate materials, manpower, machinery and money to ensure that the project is completed on time (Gray and Erik, 2008). There are several project management techniques available in the literature, but to estimate the timeline of this project the Gantt chart technique was employed, which a plot of each task against time. Each bar represents a task/activity, length of the bar corresponds to the duration of the task and the position indicate the start and finish times. The timeline for key activities of the project are shown in FIG!!!!!!!!!!!!!! below, the Gantt chart was prepared with reference to (Davda, 2004). The e ntire project is expected to take a year and 4.5 months from the Gantt chart. 6.1 Recommendations 1. Legislations and regulations are subject to changes with emergent of robust technology, therefore the design of the manufacturing facility should be above the current specifications and standards. 2. A well defined and detail engineering drawings and specifications that does not require much interpretation. 3. A good relationship between project design team with relevant regulatory authorities and encouragement of their input will fortify the design of the facility and compliance to cGMP. 4. Ensure that all designs, installations and utilities are validated according to validation master plan (VMP) and are working according to design and specification of regulatory bodies. 5. Compliance with current good manufacturing practices (cGMP) at the inception of the design phase of the facility. 6. The DNA vaccines production facility should be designed and layout to harmonized the various regulations by different bodies such the US FDA, UK MHRA, EU, Japan, ISO, WHO, etc. to boost market for the product. 7. The process parameters such as temperature, pH and pressure must be carefully controlled to assure batch-to-batch identity in final product. 7.1 Conclusion Incorporating current good manufacturing practices (cGMP) from the beginning of the design and layout phase of the DNA vaccines facility, the production processes and to the manufacturing premises will ensure that all regulatory specifications are met.

Forensic Science and its Growing Popularity Essay -- essays papers

Forensic Science and its Growing Popularity People all around the world are becoming interested in forensic science. Students across the nation are taking courses in this very popular science. Many colleges are adopting classes and majors just for it. Why has this science become so popular? Is it because of the lack of people in the field now, and the overwhelming job opportunities that come with a degree in forensic science? Is it because the field is so interesting, and catchy that everyone is flooding to be in the programs? Or is the recent growth of this field due to the numerous television and media coverage of the subject? One thing is for sure, people really are starting to get interested in this field, and it is getting bigger by the second. Forensic science, what is it exactly? Forensic Science is any aspect of any area of science that could be called into question in a court of law, as it relates to the law (http://home.earthlink.net/~thekeither/Forensic/forsone.htm). There are different areas of forensic science, and different jobs that people do. There is the crime scene investigator, as shown in the hit television show CSI: Crime Scene Investigation. They search a crime scene, collect evidence, tag/bag evidence, and analyze it. Forensic photographers take pictures at crime scenes. Forensic psychiatry and profiling is where you diagnose and treat people with mental illnesses, and where you make a personality profile of the criminal from gathering information from the crime scene. And firearms and toolmark identification, another type of forensics, is matching bullets to guns, explosives, and other weapons. These are just a few of the many different positions and jobs out there that deal with fore... ...ary 28, 2005, from The Washington Post database. Forensic science web pages. (1997). http://home.earthlink.net/~thekeither/Forensic/forsone.htm Gross, Jane. (2002). In latest science classes, dead men do tell tales. The New York Times A.1. Retrieved February 28, 2005, from The New York Times database. Richardson, Tyrone. (2005). Forensics is a favorite course: high school classes in forensic science are increasing, thanks in part to the popularity of crime scene investigation television shows. The Sun 1.G. Retrieved April 26, 2005, from The Sun database. Rockoff, Jonathan, D. (2003). Forensic science is a hot new thing: Career: Intrigued by TV shows and real life trials, students are clamoring for and getting high school and college courses in crime scene investigation. The Sun 1. A. Retrieved February 27, 2005, from The Sun database.